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Genome-wide associa...
Genome-wide association study identifies multiple loci associated with bladder cancer risk
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Figueroa, Jonine D. (author)
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Ye, Yuanqing (author)
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Siddiq, Afshan (author)
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show more...
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Garcia-Closas, Montserrat (author)
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Chatterjee, Nilanjan (author)
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Prokunina-Olsson, Ludmila (author)
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Cortessis, Victoria K. (author)
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Kooperberg, Charles (author)
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Cussenot, Olivier (author)
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Benhamou, Simone (author)
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Prescott, Jennifer (author)
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Porru, Stefano (author)
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Dinney, Colin P. (author)
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Malats, Nuria (author)
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Baris, Dalsu (author)
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Purdue, Mark (author)
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Jacobs, Eric J. (author)
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Albanes, Demetrius (author)
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Wang, Zhaoming (author)
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Deng, Xiang (author)
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Chung, Charles C. (author)
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Tang, Wei (author)
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Bueno-De-Mesquita, H. Bas (author)
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Trichopoulos, Dimitrios (author)
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- Ljungberg, Börje (author)
- Umeå universitet,Urologi och andrologi,Njurcancer
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Clavel-Chapelon, Frangoise (author)
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- Weiderpass, Elisabete (author)
- Karolinska Institutet
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Krogh, Vittorio (author)
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Dorronsoro, Miren (author)
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Travis, Ruth (author)
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Tjonneland, Anne (author)
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Brenan, Paul (author)
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Chang-Claude, Jenny (author)
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Riboli, Elio (author)
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Conti, David (author)
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Gago-Dominguez, Manuela (author)
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Stern, Mariana C. (author)
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Pike, Malcolm C. (author)
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Van den Berg, David (author)
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Yuan, Jian-Min (author)
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Hohensee, Chancellor (author)
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Rodabough, Rebecca (author)
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Cancel-Tassin, Geraldine (author)
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Roupret, Morgan (author)
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Comperat, Eva (author)
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Chen, Constance (author)
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De Vivo, Immaculata (author)
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Giovannucci, Edward (author)
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Hunter, David J. (author)
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Kraft, Peter (author)
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Lindstrom, Sara (author)
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Carta, Angela (author)
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Pavanello, Sofia (author)
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Arici, Cecilia (author)
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Mastrangelo, Giuseppe (author)
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Kamat, Ashish M. (author)
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Lerner, Seth P. (author)
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Grossman, H. Barton (author)
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Lin, Jie (author)
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Gu, Jian (author)
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Pu, Xia (author)
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Hutchinson, Amy (author)
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Burdette, Laurie (author)
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Wheeler, William (author)
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Kogevinas, Manolis (author)
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Tardon, Adonina (author)
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Serra, Consol (author)
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Carrato, Alfredo (author)
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Garcia-Closas, Reina (author)
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Lloreta, Josep (author)
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Schwenn, Molly (author)
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Karagas, Margaret R. (author)
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Johnson, Alison (author)
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Schned, Alan (author)
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Armenti, Karla R. (author)
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Hosain, G. M. (author)
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Andriole, Gerald, Jr. (author)
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Grubb, Robert, III (author)
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Black, Amanda (author)
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Diver, W. Ryan (author)
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Gapstur, Susan M. (author)
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Weinstein, Stephanie J. (author)
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Virtamo, Jarmo (author)
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Haiman, Chris A. (author)
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Landi, Maria T. (author)
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Caporaso, Neil (author)
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Fraumeni, Joseph F., Jr. (author)
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Vineis, Paolo (author)
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Wu, Xifeng (author)
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Silverman, Debra T. (author)
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Chanock, Stephen (author)
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Rothman, Nathaniel (author)
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(creator_code:org_t)
- 2013-10-24
- 2014
- English.
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In: Human Molecular Genetics. - : Oxford University Press. - 0964-6906 .- 1460-2083. ; 23:5, s. 1387-1398
- Related links:
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
Close
- andidate gene and genome-wide association studies (GWAS) have identified 11 independent susceptibility loci associated with bladder cancer risk. To discover additional risk variants, we conducted a new GWAS of 2422 bladder cancer cases and 5751 controls, followed by a meta-analysis with two independently published bladder cancer GWAS, resulting in a combined analysis of 6911 cases and 11 814 controls of European descent. TaqMan genotyping of 13 promising single nucleotide polymorphisms with P < 1 × 10−5 was pursued in a follow-up set of 801 cases and 1307 controls. Two new loci achieved genome-wide statistical significance: rs10936599 on 3q26.2 (P = 4.53 × 10−9) and rs907611 on 11p15.5 (P = 4.11 × 10−8). Two notable loci were also identified that approached genome-wide statistical significance: rs6104690 on 20p12.2 (P = 7.13 × 10−7) and rs4510656 on 6p22.3 (P = 6.98 × 10−7); these require further studies for confirmation. In conclusion, our study has identified new susceptibility alleles for bladder cancer risk that require fine-mapping and laboratory investigation, which could further understanding into the biological underpinnings of bladder carcinogenesis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Figueroa, Jonine ...
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Ye, Yuanqing
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Siddiq, Afshan
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Garcia-Closas, M ...
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Chatterjee, Nila ...
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Prokunina-Olsson ...
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show more...
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Cortessis, Victo ...
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Kooperberg, Char ...
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Cussenot, Olivie ...
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Benhamou, Simone
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Prescott, Jennif ...
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Porru, Stefano
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Dinney, Colin P.
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Malats, Nuria
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Baris, Dalsu
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Purdue, Mark
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Jacobs, Eric J.
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Albanes, Demetri ...
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Wang, Zhaoming
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Deng, Xiang
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Chung, Charles C ...
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Tang, Wei
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Bueno-De-Mesquit ...
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Trichopoulos, Di ...
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Ljungberg, Börje
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Clavel-Chapelon, ...
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Weiderpass, Elis ...
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Krogh, Vittorio
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Dorronsoro, Mire ...
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Travis, Ruth
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Tjonneland, Anne
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Brenan, Paul
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Chang-Claude, Je ...
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Riboli, Elio
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Conti, David
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Gago-Dominguez, ...
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Stern, Mariana C ...
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Pike, Malcolm C.
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Van den Berg, Da ...
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Yuan, Jian-Min
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Hohensee, Chance ...
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Rodabough, Rebec ...
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Cancel-Tassin, G ...
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Roupret, Morgan
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Comperat, Eva
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Chen, Constance
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De Vivo, Immacul ...
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Giovannucci, Edw ...
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Hunter, David J.
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Kraft, Peter
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Lindstrom, Sara
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Carta, Angela
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Pavanello, Sofia
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Arici, Cecilia
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Mastrangelo, Giu ...
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Kamat, Ashish M.
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Lerner, Seth P.
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Grossman, H. Bar ...
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Lin, Jie
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Gu, Jian
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Pu, Xia
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Hutchinson, Amy
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Burdette, Laurie
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Wheeler, William
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Kogevinas, Manol ...
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Tardon, Adonina
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Serra, Consol
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Carrato, Alfredo
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Garcia-Closas, R ...
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Lloreta, Josep
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Schwenn, Molly
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Karagas, Margare ...
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Johnson, Alison
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Schned, Alan
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Armenti, Karla R ...
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Hosain, G. M.
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Andriole, Gerald ...
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Grubb, Robert, I ...
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Black, Amanda
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Diver, W. Ryan
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Gapstur, Susan M ...
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Weinstein, Steph ...
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Virtamo, Jarmo
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Haiman, Chris A.
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Landi, Maria T.
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Caporaso, Neil
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Fraumeni, Joseph ...
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Vineis, Paolo
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Wu, Xifeng
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Silverman, Debra ...
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Chanock, Stephen
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Rothman, Nathani ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Human Molecular ...
- By the university
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Umeå University
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Karolinska Institutet