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Search: WFRF:(Fraumeni Joseph R. Jr.) > Figueroa Jonine D > Genome-wide associa...

Genome-wide association study identifies multiple loci associated with bladder cancer risk

Figueroa, Jonine D. (author)
Ye, Yuanqing (author)
Siddiq, Afshan (author)
show more...
Garcia-Closas, Montserrat (author)
Chatterjee, Nilanjan (author)
Prokunina-Olsson, Ludmila (author)
Cortessis, Victoria K. (author)
Kooperberg, Charles (author)
Cussenot, Olivier (author)
Benhamou, Simone (author)
Prescott, Jennifer (author)
Porru, Stefano (author)
Dinney, Colin P. (author)
Malats, Nuria (author)
Baris, Dalsu (author)
Purdue, Mark (author)
Jacobs, Eric J. (author)
Albanes, Demetrius (author)
Wang, Zhaoming (author)
Deng, Xiang (author)
Chung, Charles C. (author)
Tang, Wei (author)
Bueno-De-Mesquita, H. Bas (author)
Trichopoulos, Dimitrios (author)
Ljungberg, Börje (author)
Umeå universitet,Urologi och andrologi,Njurcancer
Clavel-Chapelon, Frangoise (author)
Weiderpass, Elisabete (author)
Karolinska Institutet
Krogh, Vittorio (author)
Dorronsoro, Miren (author)
Travis, Ruth (author)
Tjonneland, Anne (author)
Brenan, Paul (author)
Chang-Claude, Jenny (author)
Riboli, Elio (author)
Conti, David (author)
Gago-Dominguez, Manuela (author)
Stern, Mariana C. (author)
Pike, Malcolm C. (author)
Van den Berg, David (author)
Yuan, Jian-Min (author)
Hohensee, Chancellor (author)
Rodabough, Rebecca (author)
Cancel-Tassin, Geraldine (author)
Roupret, Morgan (author)
Comperat, Eva (author)
Chen, Constance (author)
De Vivo, Immaculata (author)
Giovannucci, Edward (author)
Hunter, David J. (author)
Kraft, Peter (author)
Lindstrom, Sara (author)
Carta, Angela (author)
Pavanello, Sofia (author)
Arici, Cecilia (author)
Mastrangelo, Giuseppe (author)
Kamat, Ashish M. (author)
Lerner, Seth P. (author)
Grossman, H. Barton (author)
Lin, Jie (author)
Gu, Jian (author)
Pu, Xia (author)
Hutchinson, Amy (author)
Burdette, Laurie (author)
Wheeler, William (author)
Kogevinas, Manolis (author)
Tardon, Adonina (author)
Serra, Consol (author)
Carrato, Alfredo (author)
Garcia-Closas, Reina (author)
Lloreta, Josep (author)
Schwenn, Molly (author)
Karagas, Margaret R. (author)
Johnson, Alison (author)
Schned, Alan (author)
Armenti, Karla R. (author)
Hosain, G. M. (author)
Andriole, Gerald, Jr. (author)
Grubb, Robert, III (author)
Black, Amanda (author)
Diver, W. Ryan (author)
Gapstur, Susan M. (author)
Weinstein, Stephanie J. (author)
Virtamo, Jarmo (author)
Haiman, Chris A. (author)
Landi, Maria T. (author)
Caporaso, Neil (author)
Fraumeni, Joseph F., Jr. (author)
Vineis, Paolo (author)
Wu, Xifeng (author)
Silverman, Debra T. (author)
Chanock, Stephen (author)
Rothman, Nathaniel (author)
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 (creator_code:org_t)
2013-10-24
2014
English.
In: Human Molecular Genetics. - : Oxford University Press. - 0964-6906 .- 1460-2083. ; 23:5, s. 1387-1398
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • andidate gene and genome-wide association studies (GWAS) have identified 11 independent susceptibility loci associated with bladder cancer risk. To discover additional risk variants, we conducted a new GWAS of 2422 bladder cancer cases and 5751 controls, followed by a meta-analysis with two independently published bladder cancer GWAS, resulting in a combined analysis of 6911 cases and 11 814 controls of European descent. TaqMan genotyping of 13 promising single nucleotide polymorphisms with P < 1 × 10−5 was pursued in a follow-up set of 801 cases and 1307 controls. Two new loci achieved genome-wide statistical significance: rs10936599 on 3q26.2 (P = 4.53 × 10−9) and rs907611 on 11p15.5 (P = 4.11 × 10−8). Two notable loci were also identified that approached genome-wide statistical significance: rs6104690 on 20p12.2 (P = 7.13 × 10−7) and rs4510656 on 6p22.3 (P = 6.98 × 10−7); these require further studies for confirmation. In conclusion, our study has identified new susceptibility alleles for bladder cancer risk that require fine-mapping and laboratory investigation, which could further understanding into the biological underpinnings of bladder carcinogenesis.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

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By the author/editor
Figueroa, Jonine ...
Ye, Yuanqing
Siddiq, Afshan
Garcia-Closas, M ...
Chatterjee, Nila ...
Prokunina-Olsson ...
show more...
Cortessis, Victo ...
Kooperberg, Char ...
Cussenot, Olivie ...
Benhamou, Simone
Prescott, Jennif ...
Porru, Stefano
Dinney, Colin P.
Malats, Nuria
Baris, Dalsu
Purdue, Mark
Jacobs, Eric J.
Albanes, Demetri ...
Wang, Zhaoming
Deng, Xiang
Chung, Charles C ...
Tang, Wei
Bueno-De-Mesquit ...
Trichopoulos, Di ...
Ljungberg, Börje
Clavel-Chapelon, ...
Weiderpass, Elis ...
Krogh, Vittorio
Dorronsoro, Mire ...
Travis, Ruth
Tjonneland, Anne
Brenan, Paul
Chang-Claude, Je ...
Riboli, Elio
Conti, David
Gago-Dominguez, ...
Stern, Mariana C ...
Pike, Malcolm C.
Van den Berg, Da ...
Yuan, Jian-Min
Hohensee, Chance ...
Rodabough, Rebec ...
Cancel-Tassin, G ...
Roupret, Morgan
Comperat, Eva
Chen, Constance
De Vivo, Immacul ...
Giovannucci, Edw ...
Hunter, David J.
Kraft, Peter
Lindstrom, Sara
Carta, Angela
Pavanello, Sofia
Arici, Cecilia
Mastrangelo, Giu ...
Kamat, Ashish M.
Lerner, Seth P.
Grossman, H. Bar ...
Lin, Jie
Gu, Jian
Pu, Xia
Hutchinson, Amy
Burdette, Laurie
Wheeler, William
Kogevinas, Manol ...
Tardon, Adonina
Serra, Consol
Carrato, Alfredo
Garcia-Closas, R ...
Lloreta, Josep
Schwenn, Molly
Karagas, Margare ...
Johnson, Alison
Schned, Alan
Armenti, Karla R ...
Hosain, G. M.
Andriole, Gerald ...
Grubb, Robert, I ...
Black, Amanda
Diver, W. Ryan
Gapstur, Susan M ...
Weinstein, Steph ...
Virtamo, Jarmo
Haiman, Chris A.
Landi, Maria T.
Caporaso, Neil
Fraumeni, Joseph ...
Vineis, Paolo
Wu, Xifeng
Silverman, Debra ...
Chanock, Stephen
Rothman, Nathani ...
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Medical Genetics
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Cancer and Oncol ...
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Cell and Molecul ...
Articles in the publication
Human Molecular ...
By the university
Umeå University
Karolinska Institutet

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